Harry Winks scored a stoppage-time winner as Tottenham came from behind to inflict a crushing 2-1 defeat on Fulham on Renault Super Sunday.
Winks applied the finishing touch to a Georges-Kevin Nkoudou cross in the third minute of added time as Spurs passed their first assignment without Harry Kane and Heung-Min Son.
Fernando Llorente, the man drafted in to replace Kane and Son, handed Fulham the lead with an own goal inside 16 minutes, but Dele Alli spared his blushes, drawing Spurs level six minutes into the second half.
Fulham looked to have secured a vital point in their battle against relegation but Winks' first goal since November 2016 saw Spurs beat a side managed by Claudio Ranieri in the Premier League for the first time, deepening their plight towards the foot of the table.
Fulham: Rico (6), Odoi (6), Le Marchand (7), Ream (6), Christie (7), Chambers (7), Seri (6), Bryan (6), Schurrle (7), Babel (7), Mitrovic (6).
Subs: Sessegnon (6), Kebano (5), Cisse (n/a).
Tottenham: Lloris (8), Alderweireld (6), Vertonghen (6), Sanchez (6), Trippier (6), Winks (8), Eriksen (7), Rose (6), Lamela (6), Alli (7), Llorente (5).
Subs: Dier (5), Nkoudou (6).
Man of the Match: Harry Winks
All the talk ahead of kick-off concerned Tottenham's ability to cope without both Kane and Son for the first time in 132 Premier League games, but it was evident early on that it would take some time for Spurs to adjust.
Fulham's recent signing Ryan Babel kicked off an impressive debut performance on 12 minutes when he outmuscled Davinson Sanchez and charged towards the area, where his fierce near-post shot was tipped behind by Hugo Lloris.
From the resulting corner, Denis Odoi shanked a shot wide from a good position but the early chances set the tone, giving Fulham confidence and belief that Spurs could be got at.
Cyrus Christie accepted the invitation to charge forward on the quarter-hour. His cross deflected behind for a corner from which Fulham took the lead as the unsighted Llorente diverted Jean Michael Seri's delivery beyond Lloris.
Llorente had the chance to atone for his clanger on 24 minutes but failed to make clear contact with Jan Vertonghen's deep cross, his effort off the shoulder dealt with by Sergio Rico.
Spurs, who were laboured and short of ideas, were fortunate to reach the interval with just the one-goal deficit as Fulham laid siege to their goal. Babel should have doubled the hosts' tally on 40 minutes but he headed over from Christie's cross.